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RIP kinase Verwandte Produkte (104)
Verwandte Produkte (104)
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Sibiriline
0 ImagesArt. -Nr.: HY-120600CAS. Nr.: 1346526-26-8Sibiriline is a specific competitive inhibitor of RIPK1 that targets the RIPK1 ATP-binding site and locks it in an inactive conformation. Sibiriline inhibits TNF-induced RIPK1-dependent necroptosis and RIPK1-dependent apoptosis, but does not protect cells from caspase-dependent apoptosis. Sibiriline protects mice from concanavalin A-induced hepatitis and has the potential to inhibit immune-dependent hepatitis..
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Necroptosis-IN-4
0 ImagesArt. -Nr.: HY-161843Necroptosis-IN-4, a potent necroptosis inhibitor, is a RIP kinase 1 (RIPK1) inhibitor. Necroptosis-IN-4 has no inhibitory activity against RIPK3 and weak inhibitory activity against VEGFR1/2 and PDGFR-α.
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TP-030-1
0 ImagesArt. -Nr.: HY-148253CAS. Nr.: 2095514-75-1TP-030-1, a chemical probe, is an inhibitor of RIPK1. TP-030-1 inhibits hRIPK1 with a Ki value of 3.9 nM and inhibits mRIPK1 with an IC50 value of 4.2 μM. TP-030-1 can be used for the research of inflammatory diseases and neurodegenerative diseases.
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RIPK2-IN-6
0 ImagesArt. -Nr.: HY-168567CAS. Nr.: 2242432-02-4
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Anticancer agent 267
0 ImagesArt. -Nr.: HY-173075Anticancer agent 267 (Compound 5q) is the activator for RIPK3 and MLKL. Anticancer agent 267 inhibits the proliferation in a variety of cancer cell lines (IC50 for MDA-MB-231, MDA-MB-486 and MCF-7 is 9.79, 10.77 and 5.94 μM, respectively), arrests cell cycle at subG1 phase, and induces necroptosis in cell MDA-MB-231. Anticancer agent 267 exhibits antitumor activity in mouse xenograft models.
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RIPK3-IN-2
0 ImagesArt. -Nr.: HY-148052CAS. Nr.: 2665669-32-7RIPK3-IN-2 is a RIP3 inhibitor. RIPK3-IN-2 can be used in diseases caused by or associate with activated necrotic pathways research.
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Ripk2 Rat Pre-designed siRNA Set A
0 ImagesArt. -Nr.: HY-RS11997
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GSK-872 (Standard)
0 ImagesArt. -Nr.: HY-101872RCAS. Nr.: 1346546-69-7GSK-872 (Standard) is the analytical standard of GSK-872 (HY-101872). This product is intended for research and analytical applications. GSK-872 is a RIPK3 inhibitor, which binds RIP3 kinase domain with an IC50 of 1.8 nM, and inhibits kinase activity with an IC50 of 1.3 nM. GSK-872 decreases the RIPK3-mediated necroptosis and subsequent cytoplasmic translocation and expression of HMGB1, as well as ameliorates brain edema and neurological deficits in early brain injury.
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GSK963 (Standard)
0 ImagesArt. -Nr.: HY-103028ARCAS. Nr.: 2049868-46-2GSK963 (Standard) is the analytical standard of GSK963 (HY-103028A). This product is intended for research and analytical applications. GSK963 is a chiral, highly potent and selective inhibitor of RIP1 kinase, with an IC50 of 29 nM. GSK963 is a selective and potent inhibitor of necroptosis in murine and human cells in vitro.
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MLKL-IN-4
0 ImagesArt. -Nr.: HY-151542CAS. Nr.: 3031406-17-1MLKL-IN-4 (compound 56) is a potent MLKL (Mixed lineage kinase domain-like protein) inhibitor. MLKL-IN-4 inhibits necroptosis in HT-29 cells and acts downstream of MLKL phosphorylation, with EC50 of 82 nM. MLKL-IN-4 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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GSK840 (Standard)
0 ImagesSynonyms: GSK'840 (Standard)GSK840 (Standard) is the analytical standard of GSK840 (HY-104021). This product is intended for research and analytical applications. GSK840 (GSK'840) is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, which binds RIP3 kinase domain with an IC50 of 0.9 nM, and inhibits kinase activity with an IC50 of 0.3 nM.
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GSK2982772 (Standard)
0 ImagesArt. -Nr.: HY-101760RCAS. Nr.: 1622848-92-3GSK2982772 (Standard) is the analytical standard of GSK2982772 (HY-101760). This product is intended for research and analytical applications. GSK2982772 is a potent, orally active and ATP competitive RIP1 kinase inhibitor with IC50 values of 16 nM and 20 nM for human and monkey RIP1, respectively.
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RIP1 Kinase inhibitor 1 (Standard)
0 ImagesArt. -Nr.: HY-111409RCAS. Nr.: 2095515-38-9RIP1 Kinase inhibitor 1 (Standard) is the analytical standard of RIP1 Kinase inhibitor 1 (HY-111409). This product is intended for research and analytical applications. RIP1 Kinase inhibitor 1 (compound 22) is a highly potent, orally available, and brain-penetrating RIP1 Kinase inhibitor (pKi=9.04).
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Necrostatin 2 racemate (Standard)
0 ImagesSynonyms: Necrostatin 1S (Standard); Nec-1S (Standard); 7-Cl-O-Nec1 (Standard)Necrostatin 2 (racemate) (Standard) is the analytical standard of Necrostatin 2 (racemate). This product is intended for research and analytical applications. Necrostatin 2 racemate (Nec-1S), the Necrostatin-1 (HY-15760) stable, is a potent and specific RIPK1 inhibitor lacking the IDO-targeting effect.
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GSK481 (Standard)
0 ImagesArt. -Nr.: HY-100131RCAS. Nr.: 1622849-58-4GSK481 (Standard) is the analytical standard of GSK481 (HY-100131). This product is intended for research and analytical applications. GSK481 is a highly potent, selective, and specific receptor interacting protein 1 (RIP1) kinase inhibitor with an IC50 of 1.3 nM, which inhibits Ser166 phosphorylation in wild-type human RIP1 (IC50=2.8 nM). GSK481 also exhibits excellent translation in the U937 cellular assay with an IC50 of 10 nM.
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GSK3145095 (Standard)
0 ImagesArt. -Nr.: HY-111946RCAS. Nr.: 1622849-43-7GSK3145095 (Standard) is the analytical standard of GSK3145095 (HY-111946). This product is intended for research and analytical applications. GSK3145095 is a RIP1 Kinase inhibitor with an IC50 of 6.3 nM .
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RIPK1-IN-24
0 ImagesArt. -Nr.: HY-162880CAS. Nr.: 1358585-26-8RIPK1-IN-24 is a receptor-interacting protein kinase 1 (RIPK1) inhibitor with an IC50 value of 1.3 μM. RIPK1-IN-24 can be used for research on inflammatory diseases.
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RIPA-56 (Standard)
0 ImagesRIPA-56 (Standard) is the analytical standard of RIPA-56 (HY-101032). This product is intended for research and analytical applications. RIPA-56 is a highly potent, selective, and metabolically stable inhibitor of receptor-interacting protein 1 (RIP1) with an IC50 of 13 nM. RIPA-56 can be used for the treatment of systemic inflammatory response syndrome.
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Cl-Necrostatin-1
0 ImagesArt. -Nr.: HY-168770CAS. Nr.: 862377-51-3Cl-Necrostatin-1 is a RIPK1 inhibitor. Cl-Necrostatin-1 can also inhibit TNF-α-induced necroptosis in Jurkat cells deficient in Fas-associated death domain protein (FADD; EC50 = 180 nM), a modification that prevents caspase activation in response to death-domain receptor signaling. Cl-Necrostatin-1 can also reduce infarct size in a mouse model of middle cerebral artery occlusion (MCAO). Cl-Necrostatin-1 is used for research in cardiovascular and cerebrovascular diseases.
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RIPK-IN-4 (Standard)
0 ImagesArt. -Nr.: HY-107978RCAS. Nr.: 2141969-56-2
